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This mechanistic complexity explains the consistent failure of nonspecific antioxidant strategies in clinical trials and supports the development of targeted interventions: mitochondria-targeted antioxidants that accumulate selectively in the matrix

Most patients begin to notice changes in body composition, energy, or recovery within 46 weeks, though optimal results are typically seen after 812 weeks of consistent use, alongside healthy lifestyle habits

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After incubation, cells were washed three times with 1 PBS to remove excess CV stain